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This gets into much more theoretical territory

The IRR of subsequent cancer was 1.73 (95% CI, 1.43 to 2.10

Indeed, FLNA can bind many different partner proteins, including transmembrane proteins, such as several GPCRs, integrins, and ion channels, allowing their anchorage to actin cytoskeleton (75), but also intracellular signaling molecules, kinases, and transcription factors [revised in Ref